Impact of lifetime body mass index trajectories on the incidence and persistence of adult asthma

GB Ali; AJ Lowe; JL Perret; EH Walters; CJ Lodge; D Johns; A James; B Erbas; GS Hamilton; G Bowatte; R Wood-Baker; MJ Abramson; DS Bui; SC Dharmage

Journal article

Impact of lifetime body mass index trajectories on the incidence and persistence of adult asthma

GB Ali, AJ Lowe, JL Perret, EH Walters, CJ Lodge, D Johns, A James, B Erbas, GS Hamilton, G Bowatte, R Wood-Baker, MJ Abramson, DS Bui, SC Dharmage

European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2022

DOI: 10.1183/13993003.02286-2021

Abstract

BACKGROUND: High body mass index (BMI) trajectories from childhood to adulthood are associated with the development of some chronic diseases, but whether such trajectories influence adult asthma has not been investigated to date. Therefore, we investigated associations between BMI trajectories from childhood to middle age (5-43 years) and incidence, persistence and relapse of asthma from ages 43 to 53 years. METHODS: In the Tasmanian Longitudinal Health Study (n=4194), weight and height were recorded at eight time-points between 5 and 43 years of age. BMI trajectories were developed using group-based trajectory modelling. Associations between BMI trajectories and asthma incidence, persistenc..

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University of Melbourne Researchers

Adrian Lowe Author

Jennifer Perret Author

Haydn Walters Author

Caroline Lodge Author

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Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by NHMRC

Funding Acknowledgements

Tasmanian Asthma Foundation supported the baseline 1968 study. Subsequent follow-ups have received funding from several sources. Funding bodies have included the National Health and Medical Research Council of Australia (grants 299901, 454425, 566931, 628513 and 1021275) ; NHMRC European collaborative grant scheme 1101313; the Australian Lung Foundation; Victorian, Queensland and Tasmanian Asthma Foundations; Clifford Craig Medical Research Trust of Tasmania; University of Melbourne; Royal Hobart Hospital Research Foundation; Helen Macpherson Smith Trust; and GlaxoSmithKline. None of the funding bodies that supported the establishment and ongoing follow-ups of the Tasmanian Longitudinal Health Study had any role in the study design, collection, analysis, interpretation of the data or writing this article. Therefore, the study design, results, conclusion and implications reported in this article are those of the authors involved in this study.